T cell activation inhibitors reduce CD8+ T cell and pro-inflammatory macrophage accumulation in adipose tissue of obese mice.

T cell activation inhibitors reduce CD8+ T cell and pro-inflammatory macrophage accumulation in adipose tissue of obese mice.

Adipose tissue inflammation and specifically, pro-inflammatory macrophages are believed to contribute to insulin resistance (IR) in obesity in humans and animal models. Recent studies have invoked T cells in the recruitment of pro-inflammatory macrophages and the development of IR. To test the role...

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Bibliographic Details
Main Authors: Vince N Montes, Michael S Turner, Savitha Subramanian, Yilei Ding, Martha Hayden-Ledbetter, Sonya Slater, Leela Goodspeed, Shari Wang, Mohamed Omer, Laura J Den Hartigh, Michelle M Averill, Kevin D O'Brien, Jeffrey Ledbetter, Alan Chait
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3699637?pdf=render

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http://europepmc.org/articles/PMC3699637?pdf=render

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