Conjugated Linoleic Acid Effects on Cancer, Obesity, and Atherosclerosis: A Review of Pre-Clinical and Human Trials with Current Perspectives

by Laura J. den Hartigh
Published 2019-02-01

Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease

by Alan Chait, Laura J. den Hartigh
Published 2020-02-01

10E,12Z-conjugated linoleic acid impairs adipocyte triglyceride storage by enhancing fatty acid oxidation, lipolysis, and mitochondrial reactive oxygen species

by Laura J. den Hartigh, Chang Yeop Han, Shari Wang, Mohamed Omer, Alan Chait
Published 2013-11-01

Aromatase deficiency in hematopoietic cells improves glucose tolerance in male mice through skeletal muscle-specific effects.

by Katya B Rubinow, Laura J den Hartigh, Leela Goodspeed, Shari Wang, Orhan K Oz
Published 2020-01-01

Deletion of serum amyloid A3 improves high fat high sucrose diet-induced adipose tissue inflammation and hyperlipidemia in female mice.

by Laura J den Hartigh, Shari Wang, Leela Goodspeed, Yilei Ding, Michelle Averill, Savitha Subramanian, Tomasz Wietecha, Kevin D O'Brien, Alan Chait
Published 2014-01-01

Postprandial apoE isoform and conformational changes associated with VLDL lipolysis products modulate monocyte inflammation.

by Laura J den Hartigh, Robin Altman, Romobia Hutchinson, Jitka Petrlova, Madhu S Budamagunta, Sarada D Tetali, Jens O Lagerstedt, John C Voss, John C Rutledge
Published 2012-01-01

10,12 Conjugated Linoleic Acid-Driven Weight Loss Is Protective against Atherosclerosis in Mice and Is Associated with Alternative Macrophage Enrichment in Perivascular Adipose Tis...

by Jenny E. Kanter, Leela Goodspeed, Shari Wang, Farah Kramer, Tomasz Wietecha, Diego Gomes-Kjerulf, Savitha Subramanian, Kevin D. O’Brien, Laura J. den Hartigh
Published 2018-10-01

The apolipoprotein-AI mimetic peptide L4F at a modest dose does not attenuate weight gain, inflammation, or atherosclerosis in LDLR-null mice.

by Michelle M Averill, Eung Ju Kim, Leela Goodspeed, Shari Wang, Savitha Subramanian, Laura J Den Hartigh, Chongren Tang, Yilei Ding, Catherine A Reardon, Godfrey S Getz, Alan Chait
Published 2014-01-01

VLDL lipolysis products increase VLDL fluidity and convert apolipoprotein E4 into a more expanded conformation

by Sarada D. Tetali, Madhu S. Budamagunta, Catalina Simion, Laura J. den Hartigh, Tamás Kálai, Kálmán Hideg, Danny M. Hatters, Karl H. Weisgraber, John C. Voss, John C. Rutledge
Published 2010-06-01

Metabolically distinct weight loss by 10,12 CLA and caloric restriction highlight the importance of subcutaneous white adipose tissue for glucose homeostasis in mice.

by Laura J den Hartigh, Shari Wang, Leela Goodspeed, Tomasz Wietecha, Barbara Houston, Mohamed Omer, Kayoko Ogimoto, Savitha Subramanian, G A Nagana Gowda, Kevin D O'Brien, Karl J Kaiyala, Gregory J Morton, Alan Chait
Published 2017-01-01

T cell activation inhibitors reduce CD8+ T cell and pro-inflammatory macrophage accumulation in adipose tissue of obese mice.

by Vince N Montes, Michael S Turner, Savitha Subramanian, Yilei Ding, Martha Hayden-Ledbetter, Sonya Slater, Leela Goodspeed, Shari Wang, Mohamed Omer, Laura J Den Hartigh, Michelle M Averill, Kevin D O'Brien, Jeffrey Ledbetter, Alan Chait
Published 2013-01-01

Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity

by Chang Yeop Han, Inkyung Kang, Ingrid A. Harten, John A. Gebe, Christina K. Chan, Mohamed Omer, Kimberly M. Alonge, Laura J. den Hartigh, Diego Gomes Kjerulf, Leela Goodspeed, Savitha Subramanian, Shari Wang, Francis Kim, David E. Birk, Thomas N. Wight, Alan Chait
Published 2020-06-01