[ 18F]FEPPA PET imaging for monitoring CD68-positive microglia/macrophage neuroinflammation in nonhuman primates

[ 18F]FEPPA PET imaging for monitoring CD68-positive microglia/macrophage neuroinflammation in nonhuman primates

Abstract Purpose The aim of this study was to examine whether the translocator protein 18-kDa (TSPO) PET ligand [18F]FEPPA has the sensitivity for detecting changes in CD68-positive microglial/macrophage activation in hemiparkinsonian rhesus macaques treated with allogeneic grafts of induced pluripo...

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Bibliographic Details
Main Authors: Matthew Zammit, Yunlong Tao, Miles E. Olsen, Jeanette Metzger, Scott C. Vermilyea, Kathryn Bjornson, Maxim Slesarev, Walter F. Block, Kerri Fuchs, Sean Phillips, Viktorya Bondarenko, Su-Chun Zhang, Marina E. Emborg, Bradley T. Christian
Format: Article
Language:English
Published: SpringerOpen 2020-08-01
Series:EJNMMI Research
Subjects:
FEPPA
TSPO
CD68
Microglia
Macrophage
Neuroinflammation
Online Access:http://link.springer.com/article/10.1186/s13550-020-00683-5

Internet

http://link.springer.com/article/10.1186/s13550-020-00683-5

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