Ezh1 Targets Bivalent Genes to Maintain Self-Renewing Stem Cells in Ezh2-Insufficient Myelodysplastic Syndrome

Ezh1 Targets Bivalent Genes to Maintain Self-Renewing Stem Cells in Ezh2-Insufficient Myelodysplastic Syndrome

Summary: Polycomb repressive complex (PRC) 2 represses transcription through histone H3K27 trimethylation (H3K27me3). We previously reported that the hematopoietic-cell-specific deletion of Ezh2, encoding a PRC2 enzyme, induced myelodysplastic syndrome (MDS) in mice, whereas the concurrent Ezh1 dele...

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Bibliographic Details
Main Authors: Kazumasa Aoyama, Motohiko Oshima, Shuhei Koide, Emi Suzuki, Makiko Mochizuki-Kashio, Yuko Kato, Shiro Tara, Daisuke Shinoda, Nobuhiro Hiura, Yaeko Nakajima-Takagi, Goro Sashida, Atsushi Iwama
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004218301676

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http://www.sciencedirect.com/science/article/pii/S2589004218301676

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