In vivo Environment Swiftly Restricts Human Pancreatic Progenitors Toward Mono-Hormonal Identity via a HNF1A/HNF4A Mechanism

In vivo Environment Swiftly Restricts Human Pancreatic Progenitors Toward Mono-Hormonal Identity via a HNF1A/HNF4A Mechanism

Generating insulin-producing β-cells from human induced pluripotent stem cells is a promising cell replacement therapy for improving or curing insulin-dependent diabetes. The transplantation of end-stages differentiating cells into living hosts was demonstrated to improve β-cell maturation. Neverthe...

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Bibliographic Details
Main Authors: Thomas Aga Legøy, Andreas F. Mathisen, Zaidon Salim, Heidrun Vethe, Yngvild Bjørlykke, Shadab Abadpour, Joao A. Paulo, Hanne Scholz, Helge Ræder, Luiza Ghila, Simona Chera
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cell identity
cell fate
differentiation
endocrine progenitors
signaling
pathway analyses
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00109/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00109/full

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