Reducing Aspergillus fumigatus Virulence through Targeted Dysregulation of the Conidiation Pathway

Reducing Aspergillus fumigatus Virulence through Targeted Dysregulation of the Conidiation Pathway

The mold Aspergillus fumigatus reproduces by the production of airborne spores (conidia), a process termed conidiation. In immunocompromised individuals, inhaled A. fumigatus conidia can germinate and form filaments that penetrate and damage lung tissues; however, conidiation does not occur during i...

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Bibliographic Details
Main Authors: James I. P. Stewart, Vinicius M. Fava, Joshua D. Kerkaert, Adithya S. Subramanian, Fabrice N. Gravelat, Melanie Lehoux, P. Lynne Howell, Robert A. Cramer, Donald C. Sheppard
Format: Article
Language:English
Published: American Society for Microbiology 2020-02-01
Series:mBio
Subjects:
aspergillus fumigatus
rna sequencing
conidiation
drug targets
inducible gene expression
opportunistic pathogen
virulence
Online Access:https://doi.org/10.1128/mBio.03202-19

Internet

https://doi.org/10.1128/mBio.03202-19

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