Megabase-scale methylation phasing using nanopore long reads and NanoMethPhase

Megabase-scale methylation phasing using nanopore long reads and NanoMethPhase

Abstract The ability of nanopore sequencing to simultaneously detect modified nucleotides while producing long reads makes it ideal for detecting and phasing allele-specific methylation. However, there is currently no complete software for detecting SNPs, phasing haplotypes, and mapping methylation...

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Bibliographic Details
Main Authors: Vahid Akbari, Jean-Michel Garant, Kieran O’Neill, Pawan Pandoh, Richard Moore, Marco A. Marra, Martin Hirst, Steven J. M. Jones
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Genome Biology
Subjects:
Nanopore sequencing
Allele-specific methylation
Phasing
NanoMethPhase
Online Access:https://doi.org/10.1186/s13059-021-02283-5

Internet

https://doi.org/10.1186/s13059-021-02283-5

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