A PITX3-EGFP Reporter Line Reveals Connectivity of Dopamine and Non-dopamine Neuronal Subtypes in Grafts Generated from Human Embryonic Stem Cells

A PITX3-EGFP Reporter Line Reveals Connectivity of Dopamine and Non-dopamine Neuronal Subtypes in Grafts Generated from Human Embryonic Stem Cells

Development of safe and effective stem cell-based therapies for brain repair requires an in-depth understanding of the in vivo properties of neural grafts generated from human stem cells. Replacing dopamine neurons in Parkinson's disease remains one of the most anticipated applications. Here, w...

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Bibliographic Details
Main Authors: Jonathan C. Niclis, Carlos W. Gantner, Cameron P.J. Hunt, Jessica A. Kauhausen, Jennifer C. Durnall, John M. Haynes, Colin W. Pouton, Clare L. Parish, Lachlan H. Thompson
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Stem Cell Reports
Subjects:
transplantation
integration
regeneration
cell-replacement therapy
embryonic stem cells
PITX3
dopamine
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117303594

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http://www.sciencedirect.com/science/article/pii/S2213671117303594

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