The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand

Schistosomiasis is caused by infection with the flatworm Schistosoma, and praziquantel is the drug of choice for its treatment. Here, Chan and colleagues identify praziquantel as a ligand for the human serotoninergic 5-HT2B G-protein-coupled receptor, and reveal a function for praziquantel as a regu...

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Bibliographic Details
Main Authors: John D. Chan, Pauline M. Cupit, Gihan S. Gunaratne, John D. McCorvy, Yang Yang, Kristen Stoltz, Thomas R. Webb, Peter I. Dosa, Bryan L. Roth, Ruben Abagyan, Charles Cunningham, Jonathan S. Marchant
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02084-0