Fibroblastic reticular cells from lymph nodes attenuate T cell expansion by producing nitric oxide.

Fibroblastic reticular cells from lymph nodes attenuate T cell expansion by producing nitric oxide.

Adaptive immune responses are initiated when T cells encounter antigen on dendritic cells (DC) in T zones of secondary lymphoid organs. T zones contain a 3-dimensional scaffold of fibroblastic reticular cells (FRC) but currently it is unclear how FRC influence T cell activation. Here we report that...

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Bibliographic Details
Main Authors: Stefanie Siegert, Hsin-Ying Huang, Chen-Ying Yang, Leonardo Scarpellino, Lucie Carrie, Sarah Essex, Peter J Nelson, Matthias Heikenwalder, Hans Acha-Orbea, Christopher D Buckley, Benjamin J Marsland, Dietmar Zehn, Sanjiv A Luther
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3215737?pdf=render

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http://europepmc.org/articles/PMC3215737?pdf=render

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