Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b

Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b

In the germinal center (GC), B and T cells interact to induce the production of protective antibodies against threats. Here the authors show that microRNA miR-146a modulates CD40 signaling in GC B cells, while both miR-146a and miR-146b synergize to control GC T cell responses, thereby implicating i...

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Bibliographic Details
Main Authors: Sunglim Cho, Hyang-Mi Lee, I-Shing Yu, Youn Soo Choi, Hsi-Yuan Huang, Somaye Sadat Hashemifar, Ling-Li Lin, Mei-Chi Chen, Nikita D. Afanasiev, Aly Azeem Khan, Shu-Wha Lin, Alexander Y. Rudensky, Shane Crotty, Li-Fan Lu
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05196-3

Internet

https://doi.org/10.1038/s41467-018-05196-3

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