Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice

Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice

Abstract Background Triggering receptor expressed on myeloid cells 2 (TREM2) is expressed in the brain exclusively on microglia and genetic variants are linked to neurodegenerative diseases including Alzheimer’s disease (AD), frontotemporal dementia (FTD) and Nasu Hakola Disease (NHD). The Trem2 var...

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Bibliographic Details
Main Authors: Vaishnavi S. Jadhav, Peter B. C. Lin, Taylor Pennington, Gonzalo Viana Di Prisco, Asha Jacob Jannu, Guixiang Xu, Miguel Moutinho, Jie Zhang, Brady K. Atwood, Shweta S. Puntambekar, Stephanie J. Bissel, Adrian L. Oblak, Gary E. Landreth, Bruce T. Lamb
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Molecular Neurodegeneration
Subjects:
NHD
Trem2-Y38C
Early-onset dementia
Transcriptomics
Oligodendrocytes/myelin
Synaptic loss
Online Access:http://link.springer.com/article/10.1186/s13024-020-00409-0

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http://link.springer.com/article/10.1186/s13024-020-00409-0

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