Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs)

Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs)

Antibody-drug conjugates (ADCs) are emerging as effective tools in cancer therapy, combining the antibody's exquisite specificity for the target antigen-expressing cancer cell together with the cytotoxic potency of the payload. Much success stems from the rational design of “toxic warheads”, ch...

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Bibliographic Details
Main Authors: Ricarda M. Hoffmann, Ben G. T. Coumbe, Debra H. Josephs, Silvia Mele, Kristina M. Ilieva, Anthony Cheung, Andrew N. Tutt, James F. Spicer, David E. Thurston, Silvia Crescioli, Sophia N. Karagiannis
Format: Article
Language:English
Published: Taylor & Francis Group 2018-03-01
Series:OncoImmunology
Subjects:
antibodies
antibody drug conjugate (adc)
biodistribution
effector functions
immunoglobulin fc
igg1
igg4
kinetics
stability
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1395127

Internet

http://dx.doi.org/10.1080/2162402X.2017.1395127

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