The Emerging Role of the Phosphatidylinositol 3-Kinase/ Akt/Mammalian Target of Rapamycin Signaling Network in Cancer Stem Cell Biology

The Emerging Role of the Phosphatidylinositol 3-Kinase/ Akt/Mammalian Target of Rapamycin Signaling Network in Cancer Stem Cell Biology

The cancer stem cell theory entails the existence of a hierarchically organized, rare population of cells which are responsible for tumor initiation, self-renewal/maintenance, and mutation accumulation. The cancer stem cell proposition could explain the high frequency of cancer relapse and resistanc...

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Bibliographic Details
Main Authors: James A. McCubrey, Camilla Evangelisti, Cecilia Grimaldi, Francesca Chiarini, Alberto M. Martelli
Format: Article
Language:English
Published: MDPI AG 2010-08-01
Series:Cancers
Subjects:
cancer stem cells
leukemic stem cells
PI3K/Akt/mTOR
proliferation
differentiation
targeted therapy
Online Access:http://www.mdpi.com/2072-6694/2/3/1576/

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http://www.mdpi.com/2072-6694/2/3/1576/

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