A novel cell-penetrating peptide derived from WT1 enhances p53 activity, induces cell senescence and displays antimelanoma activity in xeno- and syngeneic systems

A novel cell-penetrating peptide derived from WT1 enhances p53 activity, induces cell senescence and displays antimelanoma activity in xeno- and syngeneic systems

The Wilms tumor protein 1 (WT1) transcription factor has been associated in malignant melanoma with cell survival and metastasis, thus emerging as a candidate for targeted therapy. A lysine–arginine rich peptide, WT1-pTj, derived from the ZF domain of WT1 was evaluated as an antitumor agent against...

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Bibliographic Details
Main Authors: Mariana H. Massaoka, Alisson L. Matsuo, Carlos R. Figueiredo, Natalia Girola, Camyla F. Faria, Ricardo A. Azevedo, Luiz R. Travassos
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:FEBS Open Bio
Subjects:
Malignant melanoma
Wilms tumor 1 (WT1)
Senescence
p53
Online Access:http://www.sciencedirect.com/science/article/pii/S2211546314000084

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http://www.sciencedirect.com/science/article/pii/S2211546314000084

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