Rationally Designed Antibodies as Research Tools to Study the Structure–Toxicity Relationship of Amyloid-β Oligomers

Rationally Designed Antibodies as Research Tools to Study the Structure–Toxicity Relationship of Amyloid-β Oligomers

Alzheimer’s disease is associated with the aggregation of the amyloid-β peptide (Aβ), resulting in the deposition of amyloid plaques in brain tissue. Recent scrutiny of the mechanisms by which Aβ aggregates induce neuronal dysfunction has highlighted the importance of the Aβ oligomers of this protei...

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Bibliographic Details
Main Authors: Ryan Limbocker, Benedetta Mannini, Rodrigo Cataldi, Shianne Chhangur, Aidan K. Wright, Ryan P. Kreiser, J. Alex Albright, Sean Chia, Johnny Habchi, Pietro Sormanni, Janet R. Kumita, Francesco S. Ruggeri, Christopher M. Dobson, Fabrizio Chiti, Francesco A. Aprile, Michele Vendruscolo
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
protein misfolded oligomers
structure–toxicity relationship
rationally designed antibodies
research tools
biophysics
amyloid-β
Online Access:https://www.mdpi.com/1422-0067/21/12/4542

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https://www.mdpi.com/1422-0067/21/12/4542

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