N-truncated Aβ4–x peptides in sporadic Alzheimer’s disease cases and transgenic Alzheimer mouse models

N-truncated Aβ4–x peptides in sporadic Alzheimer’s disease cases and transgenic Alzheimer mouse models

Abstract Background The deposition of neurotoxic amyloid-β (Aβ) peptides in plaques in the brain parenchyma and in cerebral blood vessels is considered to be a key event in Alzheimer’s disease (AD) pathogenesis. Although the presence and impact of full-length Aβ peptides such as Aβ1–40 and Aβ1–42 ha...

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Bibliographic Details
Main Authors: Oliver Wirths, Susanne Walter, Inga Kraus, Hans W. Klafki, Martina Stazi, Timo J. Oberstein, Jorge Ghiso, Jens Wiltfang, Thomas A. Bayer, Sascha Weggen
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
N-truncated Amyloid-β
Immunohistochemistry
Mouse model
Postmortem
5XFAD
Online Access:http://link.springer.com/article/10.1186/s13195-017-0309-z

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http://link.springer.com/article/10.1186/s13195-017-0309-z

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