Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease

Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease

Abstract Background Alzheimer’s disease (AD) is the most common form of dementia, characterized by progressive cognitive impairment and neurodegeneration. However, despite extensive clinical and genomic studies, the molecular basis of AD development and progression remains elusive. Methods To elucid...

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Bibliographic Details
Main Authors: Minghui Wang, Panos Roussos, Andrew McKenzie, Xianxiao Zhou, Yuji Kajiwara, Kristen J. Brennand, Gabriele C. De Luca, John F. Crary, Patrizia Casaccia, Joseph D. Buxbaum, Michelle Ehrlich, Sam Gandy, Alison Goate, Pavel Katsel, Eric Schadt, Vahram Haroutunian, Bin Zhang
Format: Article
Language:English
Published: BMC 2016-11-01
Series:Genome Medicine
Subjects:
Alzheimer’s disease
Dementia
Differential expression
Gene co-expression network
Gene module
Systems biology
Online Access:http://link.springer.com/article/10.1186/s13073-016-0355-3

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http://link.springer.com/article/10.1186/s13073-016-0355-3

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