The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis.

The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis.

BACKGROUND: GP-BAR1, a member G protein coupled receptor superfamily, is a cell surface bile acid-activated receptor highly expressed in the ileum and colon. In monocytes, ligation of GP-BAR1 by secondary bile acids results in a cAMP-dependent attenuation of cytokine generation. AIMS: To investigate...

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Bibliographic Details
Main Authors: Sabrina Cipriani, Andrea Mencarelli, Maria Giovanna Chini, Eleonora Distrutti, Barbara Renga, Giuseppe Bifulco, Franco Baldelli, Annibale Donini, Stefano Fiorucci
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3203117?pdf=render

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http://europepmc.org/articles/PMC3203117?pdf=render

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