Regulated protein expression for in vivo gene therapy for neurological disorders: Progress, strategies, and issues

The field of in vivo gene therapy has matured to the point where there are numerous clinical trials underway including late-stage clinical trials. Several viral vectors are especially efficient and support lifetime protein expression in the brain and a number of clinical trials are underway for vari...

Full description

Bibliographic Details
Main Authors: Fredric P. Manfredsson, David C. Bloom, Ronald J. Mandel
Format: Article
Language:English
Published: Elsevier 2012-11-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112000721