Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells

Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells

Pilocytic astrocytoma is a low-grade pediatric glioma, characterized by a single BRAF rearrangement. Here, Reitman and colleagues use single-cell RNA sequencing to reveal molecular hallmarks of the disease that might be targeted therapeutically.

Bibliographic Details
Main Authors:	Zachary J. Reitman, Brenton R. Paolella, Guillaume Bergthold, Kristine Pelton, Sarah Becker, Robert Jones, Claire E. Sinai, Hayley Malkin, Ying Huang, Leslie Grimmet, Zachary T. Herbert, Yu Sun, Jessica L. Weatherbee, John A. Alberta, John F. Daley, Orit Rozenblatt-Rosen, Alexandra L. Condurat, Kenin Qian, Prasidda Khadka, Rosalind A. Segal, Daphne Haas-Kogan, Mariella G. Filbin, Mario L. Suva, Aviv Regev, Charles D. Stiles, Mark W. Kieran, Liliana Goumnerova, Keith L. Ligon, Alex K. Shalek, Pratiti Bandopadhayay, Rameen Beroukhim
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-11493-2

Internet

https://doi.org/10.1038/s41467-019-11493-2