Removal of the N-Glycosylation Sequon at Position N116 Located in p27 of the Respiratory Syncytial Virus Fusion Protein Elicits Enhanced Antibody Responses after DNA Immunization

Removal of the N-Glycosylation Sequon at Position N116 Located in p27 of the Respiratory Syncytial Virus Fusion Protein Elicits Enhanced Antibody Responses after DNA Immunization

Prevention of severe lower respiratory tract infections in infants caused by the human respiratory syncytial virus (hRSV) remains a major public health priority. Currently, the major focus of vaccine development relies on the RSV fusion (F) protein since it is the main target protein for neutralizin...

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Bibliographic Details
Main Authors: Annelies Leemans, Marlies Boeren, Winke Van der Gucht, Isabel Pintelon, Kenny Roose, Bert Schepens, Xavier Saelens, Dalan Bailey, Wim Martinet, Guy Caljon, Louis Maes, Paul Cos, Peter Delputte
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Viruses
Subjects:
class I fusion protein
virus glycosylation
DNA immunization
humoral responses
pneumovirus
vaccine
Online Access:http://www.mdpi.com/1999-4915/10/8/426

Internet

http://www.mdpi.com/1999-4915/10/8/426

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