Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo.

Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo.

Protein kinase B (PKB/Akt) is a pivotal regulator of diverse metabolic, phenotypic, and antiapoptotic cellular controls and has been shown to be a key player in cancer progression. Here, using fluorescent reporters, we shown in cells that, contrary to in vitro analyses, 3-phosphoinositide-dependent...

Full description

Bibliographic Details
Main Authors: Véronique Calleja, Damien Alcor, Michel Laguerre, Jongsun Park, Borivoj Vojnovic, Brian A Hemmings, Julian Downward, Peter J Parker, Banafshé Larijani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-04-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC1845162?pdf=render

Internet

http://europepmc.org/articles/PMC1845162?pdf=render

Similar Items