Generation of human antigen-specific monoclonal IgM antibodies using vaccinated "human immune system" mice.

Generation of human antigen-specific monoclonal IgM antibodies using vaccinated "human immune system" mice.

Passive transfer of antibodies not only provides immediate short-term protection against disease, but also can be exploited as a therapeutic tool. However, the 'humanization' of murine monoclonal antibodies (mAbs) is a time-consuming and expensive process that has the inherent drawback of...

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Bibliographic Details
Main Authors: Pablo D Becker, Nicolas Legrand, Caroline M M van Geelen, Miriam Noerder, Nicholas D Huntington, Annick Lim, Etsuko Yasuda, Sean A Diehl, Ferenc A Scheeren, Michael Ott, Kees Weijer, Heiner Wedemeyer, James P Di Santo, Tim Beaumont, Carlos A Guzman, Hergen Spits
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2949385?pdf=render

Internet

http://europepmc.org/articles/PMC2949385?pdf=render

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