Deficiency of Invariant Natural Killer T Cells Does Not Protect Against Obesity but Exacerbates Atherosclerosis in Ldlr−/− Mice

Deficiency of Invariant Natural Killer T Cells Does Not Protect Against Obesity but Exacerbates Atherosclerosis in Ldlr−/− Mice

Obesity is a chronic inflammatory state characterized by altered levels of adipose tissue immune cell populations. Natural killer T (NKT) cells are CD1d restricted lymphocyte subsets that recognize lipid antigens whose level decreases in obese adipose tissue. However, studies in mice with deficiency...

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Bibliographic Details
Main Authors: Savitha Subramanian, Leela Goodspeed, Shari Wang, Yilei Ding, Kevin D. O’Brien, Godfrey S. Getz, Alan Chait, Catherine A. Reardon
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:International Journal of Molecular Sciences
Subjects:
natural killer T cells
adipose tissue
atherosclerosis
inflammation
Online Access:http://www.mdpi.com/1422-0067/19/2/510

Internet

http://www.mdpi.com/1422-0067/19/2/510

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