Effect of Seven Newly Synthesized and Currently Available Oxime Cholinesterase Reactivators on Cyclosarin-Intoxicated Rats

Effect of Seven Newly Synthesized and Currently Available Oxime Cholinesterase Reactivators on Cyclosarin-Intoxicated Rats

Seven new oxime-based acetylcholinesterase reactivators were compared with three currently available ones (obidoxime, trimedoxime, HI-6) for their ability to lessen cholinesterase inhibition in blood and brain of cyclosarin-treated rats. Oximes were given at doses of 5% their LD50 along with 21 mg/k...

Full description

Bibliographic Details
Main Authors: Kamil Kuca, Ladislav Novotny, Kamil Musilek, Miroslav Pohanka, Jiri Kassa, Jana Zdarova Karasova
Format: Article
Language:English
Published: MDPI AG 2009-07-01
Series:International Journal of Molecular Sciences
Subjects:
acetylcholinesterase
butyrylcholinesterase
reactivators
oximes
cyclosarin
Online Access:http://www.mdpi.com/1422-0067/10/7/3065/

Internet

http://www.mdpi.com/1422-0067/10/7/3065/

Similar Items