Circulating histone H3 levels in septic patients are associated with coagulopathy, multiple organ failure, and death: a single-center observational study

Circulating histone H3 levels in septic patients are associated with coagulopathy, multiple organ failure, and death: a single-center observational study

Abstract Background Nuclear histone proteins are released into the extracellular space, and act as major mediators of coagulopathy and remote organ failure in septic animals. However, the circulating histone levels in septic patients have not been precisely quantified. Methods Using a novel enzyme-l...

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Bibliographic Details
Main Authors: Yayoi Yokoyama, Takashi Ito, Tomotsugu Yasuda, Hiroaki Furubeppu, Chinatsu Kamikokuryo, Shingo Yamada, Ikuro Maruyama, Yasuyuki Kakihana
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Thrombosis Journal
Subjects:
Histone
Sepsis
Coagulopathy
Organ failure
Online Access:http://link.springer.com/article/10.1186/s12959-018-0190-4

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http://link.springer.com/article/10.1186/s12959-018-0190-4

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