A switch in transcription and cell fate governs the onset of an epigenetically-deregulated tumor in Drosophila

A switch in transcription and cell fate governs the onset of an epigenetically-deregulated tumor in Drosophila

Tumor initiation is often linked to a loss of cellular identity. Transcriptional programs determining cellular identity are preserved by epigenetically-acting chromatin factors. Although such regulators are among the most frequently mutated genes in cancer, it is not well understood how an abnormal...

Full description

Bibliographic Details
Main Authors: Joana Torres, Remo Monti, Ariane L Moore, Makiko Seimiya, Yanrui Jiang, Niko Beerenwinkel, Christian Beisel, Jorge V Beira, Renato Paro
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-03-01
Series:eLife
Subjects:
dedifferentiation
embryonic-TF signature
transcription factors
epigenetic regulation
tumor onset
cell fate loss
Online Access:https://elifesciences.org/articles/32697

Internet

https://elifesciences.org/articles/32697

Similar Items