The toll-like receptor signaling molecule Myd88 contributes to pancreatic beta-cell homeostasis in response to injury.

The toll-like receptor signaling molecule Myd88 contributes to pancreatic beta-cell homeostasis in response to injury.

Commensal flora and pathogenic microbes influence the incidence of diabetes in animal models yet little is known about the mechanistic basis of these interactions. We hypothesized that Myd88, an adaptor molecule in the Toll-like-receptor (TLR) pathway, regulates pancreatic beta-cell function and hom...

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Bibliographic Details
Main Authors: Paul L Bollyky, Jeffrey B Bice, Ian R Sweet, Ben A Falk, John A Gebe, April E Clark, Vivian H Gersuk, Alan Aderem, Thomas R Hawn, Gerald T Nepom
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2666970?pdf=render

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http://europepmc.org/articles/PMC2666970?pdf=render

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