Hypergastrinemia Expands Gastric ECL Cells Through CCK2R+ Progenitor Cells via ERK ActivationSummary

Hypergastrinemia Expands Gastric ECL Cells Through CCK2R+ Progenitor Cells via ERK ActivationSummary

Background & Aims: Enterochromaffin-like (ECL) cells in the stomach express gastrin/cholecystokinin 2 receptor CCK2R and are known to expand under hypergastrinemia, but whether this results from expansion of existing ECL cells or increased production from progenitors has not been clarified....

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Bibliographic Details
Main Authors: Weiwei Sheng, Ermanno Malagola, Henrik Nienhüser, Zhengyu Zhang, Woosook Kim, Leah Zamechek, Antonia Sepulveda, Masahiro Hata, Yoku Hayakawa, Chun-Mei Zhao, Duan Chen, Timothy C. Wang
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Enterochromaffin-Like (ECL) Cells
Progenitor Cell
CCK2R or Gastrin Receptor
Gastrin
Stem Cell Niche
Histidine Decarboxylase (Hdc)
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X20300527

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http://www.sciencedirect.com/science/article/pii/S2352345X20300527

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