Isolation of monoclonal antibodies with predetermined conformational epitope specificity.

Isolation of monoclonal antibodies with predetermined conformational epitope specificity.

Existing technologies allow isolating antigen-specific monoclonal antibodies (mAbs) from B cells. We devised a direct approach to isolate mAbs with predetermined conformational epitope specificity, using epitope mimetics (mimotopes) that reflect the three-dimensional structure of given antigen subdo...

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Bibliographic Details
Main Authors: Anton M Sholukh, Muhammad M Mukhtar, Michael Humbert, Sosthène S Essono, Jennifer D Watkins, Hemant K Vyas, Vivekanandan Shanmuganathan, Girish Hemashettar, Maria Kahn, Shiu-Lok Hu, David C Montefiori, Victoria R Polonis, Peter H Schur, Ruth M Ruprecht
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3380854?pdf=render

Internet

http://europepmc.org/articles/PMC3380854?pdf=render

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