Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes

Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes

Abstract Background Obesity predisposes individuals to multiple cardiometabolic disorders, including type 2 diabetes (T2D). As body mass index (BMI) cannot reliably differentiate fat from lean mass, the metabolically detrimental abdominal obesity has been estimated using waist-hip ratio (WHR). Waist...

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Main Authors: David Z. Pan, Zong Miao, Caroline Comenho, Sandhya Rajkumar, Amogha Koka, Seung Hyuk T. Lee, Marcus Alvarez, Dorota Kaminska, Arthur Ko, Janet S. Sinsheimer, Karen L. Mohlke, Nicholas Mancuso, Linda Liliana Muñoz-Hernandez, Miguel Herrera-Hernandez, Maria Teresa Tusié-Luna, Carlos Aguilar-Salinas, Kirsi H. Pietiläinen, Jussi Pihlajamäki, Markku Laakso, Kristina M. Garske, Päivi Pajukanta
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Genome Medicine
Subjects:
Transcriptional regulation of abdominal obesity
Master transcription factor
Trans regulation of genes
Waist-hip ratio adjusted for body mass index (WHRadjBMI)
Type 2 diabetes (T2D)
Polygenic risk score (PRS)
Online Access:https://doi.org/10.1186/s13073-021-00939-2

Internet

https://doi.org/10.1186/s13073-021-00939-2

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