Mutagenesis of DsbAss is Crucial for the Signal Recognition Particle Mechanism in <i>Escherichia coli</i>: Insights from Molecular Dynamics Simulations

Mutagenesis of DsbAss is Crucial for the Signal Recognition Particle Mechanism in <i>Escherichia coli</i>: Insights from Molecular Dynamics Simulations

The disulfide bond signal sequence (DsbAss) protein is characterized as an important virulence factor in gram-negative bacteria. This study aimed to analyze the &#8220;alanine&#8222; alteration in the hydrophobic (H) region of DsbAss and to understand the conformational DsbAss alteration(s)...

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Bibliographic Details
Main Authors: Faiza Gul Durrani, Roquyya Gul, Muhammad Usman Mirza, Naheed Nazly Kaderbhai, Matheus Froeyen, Mahjabeen Saleem
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Biomolecules
Subjects:
DsbA signal sequence
ovine growth hormone
signal recognition particle system
molecular dynamics simulation
molecular mechanics generalized born surface area
Online Access:https://www.mdpi.com/2218-273X/9/4/133

Internet

https://www.mdpi.com/2218-273X/9/4/133

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