Altered DNA Methylation Profiles in <i>SF3B1</i> Mutated CLL Patients

Altered DNA Methylation Profiles in <i>SF3B1</i> Mutated CLL Patients

Mutations in splicing factor genes have a severe impact on the survival of cancer patients. Splicing factor 3b subunit 1 (<i>SF3B1</i>) is one of the most frequently mutated genes in chronic lymphocytic leukemia (CLL); patients carrying these mutations have a poor prognosis. Since the sp...

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Bibliographic Details
Main Authors: Alicja Pacholewska, Christina Grimm, Carmen D. Herling, Matthias Lienhard, Anja Königs, Bernd Timmermann, Janine Altmüller, Oliver Mücke, Hans Christian Reinhardt, Christoph Plass, Ralf Herwig, Michael Hallek, Michal R. Schweiger
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
chronic lymphocytic leukemia
CLL
DNA methylation
<i>SF3B1</i> mutation
NOTCH
IKAROS
Online Access:https://www.mdpi.com/1422-0067/22/17/9337

Internet

https://www.mdpi.com/1422-0067/22/17/9337

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