AID Overlapping and Polη Hotspots Are Key Features of Evolutionary Variation Within the Human Antibody Heavy Chain (IGHV) Genes

AID Overlapping and Polη Hotspots Are Key Features of Evolutionary Variation Within the Human Antibody Heavy Chain (IGHV) Genes

Somatic hypermutation (SHM) of the immunoglobulin variable (IgV) loci is a key process in antibody affinity maturation. The enzyme activation-induced deaminase (AID), initiates SHM by creating C → U mismatches on single-stranded DNA (ssDNA). AID has preferential hotspot motif targets in the context...

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Bibliographic Details
Main Authors: Catherine Tang, Davide Bagnara, Nicholas Chiorazzi, Matthew D. Scharff, Thomas MacCarthy
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
somatic hypermutation (SHM)
activation induced deaminase (AID)
immunoglobulin heavy chain
computational immunology
B cell receptor (BCR)
dimensionality reduction
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00788/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00788/full

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