Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress

Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress

The transcription factor Nrf2 is a stress-responsive master regulator of antioxidant, detoxification and proteostasis genes. In astrocytes, Nrf2-dependent gene expression drives cell-autonomous cytoprotection and also non-cell-autonomous protection of nearby neurons, and can ameliorate pathology in...

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Bibliographic Details
Main Authors: Bashayer R. Al-Mubarak, Karen F.S. Bell, Sudhir Chowdhry, Paul J. Meakin, Paul S. Baxter, Sean McKay, Owen Dando, Michael L.J. Ashford, Irina Gazaryan, John D. Hayes, Giles E. Hardingham
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Redox Biology
Subjects:
Astrocytes
Gene transcription
NRF2
Keap1
Oxidative stress
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721003189

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http://www.sciencedirect.com/science/article/pii/S2213231721003189

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