Nucleobase but not Sugar Fidelity is Maintained in the Sabin I RNA-Dependent RNA Polymerase

Nucleobase but not Sugar Fidelity is Maintained in the Sabin I RNA-Dependent RNA Polymerase

The Sabin I poliovirus live, attenuated vaccine strain encodes for four amino acid changes (i.e., D53N, Y73H, K250E, and T362I) in the RNA-dependent RNA polymerase (RdRp). We have previously shown that the T362I substitution leads to a lower fidelity RdRp, and viruses encoding this variant are atten...

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Bibliographic Details
Main Authors: Xinran Liu, Derek M. Musser, Cheri A. Lee, Xiaorong Yang, Jamie J. Arnold, Craig E. Cameron, David D. Boehr
Format: Article
Language:English
Published: MDPI AG 2015-10-01
Series:Viruses
Subjects:
enterovirus
poliovirus
Sabin
oral poliovirus vaccine
vaccine-associated paralytic poliovirus
vaccine-derived poliovirus
RNA-dependent RNA polymerase
polymerase fidelity
Online Access:http://www.mdpi.com/1999-4915/7/10/2894

Internet

http://www.mdpi.com/1999-4915/7/10/2894

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