Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

Previous studies demonstrate that intrastriatal injections of fibrillar alpha-synuclein (α-syn) into mice induce Parkinson's disease (PD)-like Lewy body (LB) pathology formed by aggregated α-syn in anatomically interconnected regions and significant nigrostriatal degeneration. The aim of the cu...

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Bibliographic Details
Main Authors: Katrina L. Paumier, Kelvin C. Luk, Fredric P. Manfredsson, Nicholas M. Kanaan, Jack W. Lipton, Timothy J. Collier, Kathy Steece-Collier, Christopher J. Kemp, Stephanie Celano, Emily Schulz, Ivette M. Sandoval, Sheila Fleming, Elliott Dirr, Nicole K. Polinski, John Q. Trojanowski, Virginia M. Lee, Caryl E. Sortwell
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Neurobiology of Disease
Subjects:
Pre-formed fibrils
Alpha-synuclein
Propagation
Neurodegeneration
Rats
Parkinson's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115002211

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http://www.sciencedirect.com/science/article/pii/S0969996115002211

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