The peptidyl prolyl cis/trans isomerase Pin1/Ess1 inhibits phosphorylation and toxicity of tau in a yeast model for Alzheimer’s disease

The peptidyl prolyl cis/trans isomerase Pin1/Ess1 inhibits phosphorylation and toxicity of tau in a yeast model for Alzheimer’s disease

Since hyperphosphorylation of protein tau is a crucial event in Alzheimer’s disease, additional mechanisms besides the interplay of kinase and phosphatase activities are investigated, such as the effect of the peptidyl prolyl cis/trans isomerase Pin1. This isomerase was shown to bind and isomerize p...

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Bibliographic Details
Main Authors: Ann De Vos, Tine Bynens, Joëlle Rosseels, Catherina Coun, Julia Ring, Frank Madeo, Marie-Christine Galas, Joris Winderickx, Vanessa Franssens
Format: Article
Language:English
Published: AIMS Press 2015-04-01
Series:AIMS Molecular Science
Subjects:
Pin1
tau
yeast
phosphorylation
Alzheimer’s dis
Alzheimer’s disease
Online Access:http://www.aimspress.com/article/10.3934/molsci.2015.2.144/fulltext.html

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http://www.aimspress.com/article/10.3934/molsci.2015.2.144/fulltext.html

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