Methylisoindigo and Its Bromo-Derivatives Are Selective Tyrosine Kinase Inhibitors, Repressing Cellular Stat3 Activity, and Target CD133+ Cancer Stem Cells in PDAC

Methylisoindigo and Its Bromo-Derivatives Are Selective Tyrosine Kinase Inhibitors, Repressing Cellular Stat3 Activity, and Target CD133+ Cancer Stem Cells in PDAC

Indirubin is an active component of the herbal ingredient ‘Danggui Longhui wan’, which was used for the treatment of inflammation and chronic myeloid leukemia in China. The recent study showed its derivative methylisoindigo (also known as meisoindigo) preferentially targeting cancer stem cells (CSCs...

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Bibliographic Details
Main Authors: Jana Tegethoff, Roland Bischoff, Sawsan Saleh, Biljana Blagojevic, Karl-Heinz Merz, Xinlai Cheng
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Molecules
Subjects:
indirubin
meisoindigo
cancer stem cells
Stat3 inhibitor
selective protein kinase inhibitor
TCM
structure-activity-relationship
Online Access:https://www.mdpi.com/1420-3049/22/9/1546

Internet

https://www.mdpi.com/1420-3049/22/9/1546

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