Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study

Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study

The ability to investigate therapeutic interventions in animal models of neurodegenerative diseases depends on extensive characterization of the model(s) being used. There are numerous models that have been generated to study Alzheimer’s disease (AD) and the underlying pathogenesis of the disease. W...

Full description

Bibliographic Details
Main Authors: Adrian L. Oblak, Peter B. Lin, Kevin P. Kotredes, Ravi S. Pandey, Dylan Garceau, Harriet M. Williams, Asli Uyar, Rita O’Rourke, Sarah O’Rourke, Cynthia Ingraham, Daria Bednarczyk, Melisa Belanger, Zackary A. Cope, Gabriela J. Little, Sean-Paul G. Williams, Carl Ash, Adam Bleckert, Tim Ragan, Benjamin A. Logsdon, Lara M. Mangravite, Stacey J. Sukoff Rizzo, Paul R. Territo, Gregory W. Carter, Gareth R. Howell, Michael Sasner, Bruce T. Lamb
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
phenotyping
animal model
early-onset AD
MODEL-AD
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.713726/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2021.713726/full

Similar Items