The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans.

The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans.

The cyclic GMP-AMP synthase (cGAS)-STING pathway is central for innate immune sensing of various bacterial, viral and protozoal infections. Recent studies identified the common HAQ and R232H alleles of TMEM173/STING, but the functional consequences of these variants for primary infections are unknow...

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Main Authors: Juan S Ruiz-Moreno, Lutz Hamann, Javeed A Shah, Annelies Verbon, Frank P Mockenhaupt, Monika Puzianowska-Kuznicka, Jan Naujoks, Leif E Sander, Martin Witzenrath, John C Cambier, Norbert Suttorp, Ralf R Schumann, Lei Jin, Thomas R Hawn, Bastian Opitz, CAPNETZ Study Group
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1006829

Internet

https://doi.org/10.1371/journal.ppat.1006829

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