Open Chromatin Profiling in Adipose Tissue Marks Genomic Regions with Functional Roles in Cardiometabolic Traits

Open Chromatin Profiling in Adipose Tissue Marks Genomic Regions with Functional Roles in Cardiometabolic Traits

Identifying the regulatory mechanisms of genome-wide association study (GWAS) loci affecting adipose tissue has been restricted due to limited characterization of adipose transcriptional regulatory elements. We profiled chromatin accessibility in three frozen human subcutaneous adipose tissue needle...

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Bibliographic Details
Main Authors: Maren E. Cannon, Kevin W. Currin, Kristin L. Young, Hannah J. Perrin, Swarooparani Vadlamudi, Alexias Safi, Lingyun Song, Ying Wu, Martin Wabitsch, Markku Laakso, Gregory E. Crawford, Karen L. Mohlke
Format: Article
Language:English
Published: Oxford University Press 2019-08-01
Series:G3: Genes, Genomes, Genetics
Subjects:
chromatin accessibility
adipose tissue
preadipocytes
GWAS
cardiometabolic trait
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.119.400294

Internet

http://g3journal.org/lookup/doi/10.1534/g3.119.400294

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