Genomic Determinants of Protein Abundance Variation in Colorectal Cancer Cells

Genomic Determinants of Protein Abundance Variation in Colorectal Cancer Cells

Assessing the impact of genomic alterations on protein networks is fundamental in identifying the mechanisms that shape cancer heterogeneity. We have used isobaric labeling to characterize the proteomic landscapes of 50 colorectal cancer cell lines and to decipher the functional consequences of soma...

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Bibliographic Details
Main Authors: Theodoros I. Roumeliotis, Steven P. Williams, Emanuel Gonçalves, Clara Alsinet, Martin Del Castillo Velasco-Herrera, Nanne Aben, Fatemeh Zamanzad Ghavidel, Magali Michaut, Michael Schubert, Stacey Price, James C. Wright, Lu Yu, Mi Yang, Rodrigo Dienstmann, Justin Guinney, Pedro Beltrao, Alvis Brazma, Mercedes Pardo, Oliver Stegle, David J. Adams, Lodewyk Wessels, Julio Saez-Rodriguez, Ultan McDermott, Jyoti S. Choudhary
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Cell Reports
Subjects:
proteomics
TMT
protein complexes
networks
phosphorylation
mutations
CRISPR/cas9
colorectal cancer
cell lines
drug response
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717311002

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http://www.sciencedirect.com/science/article/pii/S2211124717311002

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