Docking, synthesis and antiproliferative activity of N-acylhydrazone derivatives designed as combretastatin A4 analogues.

Docking, synthesis and antiproliferative activity of N-acylhydrazone derivatives designed as combretastatin A4 analogues.

Cancer is the second most common cause of death in the USA. Among the known classes of anticancer agents, the microtubule-targeted antimitotic drugs are considered to be one of the most important. They are usually classified into microtubule-destabilizing (e.g., Vinca alkaloids) and microtubule-stab...

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Main Authors: Daniel Nascimento do Amaral, Bruno C Cavalcanti, Daniel P Bezerra, Paulo Michel P Ferreira, Rosane de Paula Castro, José Ricardo Sabino, Camila Maria Longo Machado, Roger Chammas, Claudia Pessoa, Carlos M R Sant'Anna, Eliezer J Barreiro, Lídia Moreira Lima
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3948622?pdf=render

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http://europepmc.org/articles/PMC3948622?pdf=render

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