Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis
Beta3-adrenergic receptor signaling regulates adipose tissue browning. Here, the authors show that barr2 regulates internalization of beta3-adrenergic receptors and that mice lacking barr2 in adipocytes are protected from diet-induced weight gain and metabolic complications.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11003-4 |
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doaj-db4766c456f2475085560b5fbc6645dc2021-05-11T12:09:53ZengNature Publishing GroupNature Communications2041-17232019-07-0110111410.1038/s41467-019-11003-4Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasisSai P. Pydi0Shanu Jain1Wesley Tung2Yinghong Cui3Lu Zhu4Wataru Sakamoto5Shalini Jain6Brent S. Abel7Monica C. Skarulis8Jie Liu9Thanh Huynh10Karel Pacak11Marc G. Caron12Oksana Gavrilova13Toren Finkel14Jürgen Wess15Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney DiseasesMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney DiseasesMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney DiseasesMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney DiseasesMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney DiseasesMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney DiseasesMouse Metabolism Core, National Institute of Diabetes and Digestive and Kidney DiseasesDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney DiseasesDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney DiseasesCenter for Molecular Medicine, National Heart, Lung, and Blood InstituteSection on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentSection on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentDepartment of Cell Biology, Duke University Medical CenterMouse Metabolism Core, National Institute of Diabetes and Digestive and Kidney DiseasesCenter for Molecular Medicine, National Heart, Lung, and Blood InstituteMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney DiseasesBeta3-adrenergic receptor signaling regulates adipose tissue browning. Here, the authors show that barr2 regulates internalization of beta3-adrenergic receptors and that mice lacking barr2 in adipocytes are protected from diet-induced weight gain and metabolic complications.https://doi.org/10.1038/s41467-019-11003-4 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Sai P. Pydi Shanu Jain Wesley Tung Yinghong Cui Lu Zhu Wataru Sakamoto Shalini Jain Brent S. Abel Monica C. Skarulis Jie Liu Thanh Huynh Karel Pacak Marc G. Caron Oksana Gavrilova Toren Finkel Jürgen Wess |
| spellingShingle |
Sai P. Pydi Shanu Jain Wesley Tung Yinghong Cui Lu Zhu Wataru Sakamoto Shalini Jain Brent S. Abel Monica C. Skarulis Jie Liu Thanh Huynh Karel Pacak Marc G. Caron Oksana Gavrilova Toren Finkel Jürgen Wess Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis Nature Communications |
| author_facet |
Sai P. Pydi Shanu Jain Wesley Tung Yinghong Cui Lu Zhu Wataru Sakamoto Shalini Jain Brent S. Abel Monica C. Skarulis Jie Liu Thanh Huynh Karel Pacak Marc G. Caron Oksana Gavrilova Toren Finkel Jürgen Wess |
| author_sort |
Sai P. Pydi |
| title |
Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis |
| title_short |
Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis |
| title_full |
Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis |
| title_fullStr |
Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis |
| title_full_unstemmed |
Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis |
| title_sort |
adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-07-01 |
| description |
Beta3-adrenergic receptor signaling regulates adipose tissue browning. Here, the authors show that barr2 regulates internalization of beta3-adrenergic receptors and that mice lacking barr2 in adipocytes are protected from diet-induced weight gain and metabolic complications. |
| url |
https://doi.org/10.1038/s41467-019-11003-4 |
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