Discovery of human coronaviruses pan-papain-like protease inhibitors using computational approaches

Discovery of human coronaviruses pan-papain-like protease inhibitors using computational approaches

The papain-like protease (PLpro) is vital for the replication of coronaviruses (CoVs), as well as for escaping innate-immune responses of the host. Hence, it has emerged as an attractive antiviral drug-target. In this study, computational approaches were employed, mainly the structure-based virtual...

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Bibliographic Details
Main Authors: Mubarak A. Alamri, Muhammad Tahir ul Qamar, Muhammad Usman Mirza, Safar M. Alqahtani, Matheus Froeyen, Ling-Ling Chen
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Journal of Pharmaceutical Analysis
Subjects:
COVID-19
MERS-CoV
Molecular dynamic simulation
Pan-inhibitors
Papain-like protease
SARS-CoV
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177920310558

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http://www.sciencedirect.com/science/article/pii/S2095177920310558

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