Discovery of human coronaviruses pan-papain-like protease inhibitors using computational approaches
The papain-like protease (PLpro) is vital for the replication of coronaviruses (CoVs), as well as for escaping innate-immune responses of the host. Hence, it has emerged as an attractive antiviral drug-target. In this study, computational approaches were employed, mainly the structure-based virtual...
Main Authors: | Mubarak A. Alamri, Muhammad Tahir ul Qamar, Muhammad Usman Mirza, Safar M. Alqahtani, Matheus Froeyen, Ling-Ling Chen |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2020-12-01
|
Series: | Journal of Pharmaceutical Analysis |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2095177920310558 |
Similar Items
-
Non-Toxic Dimeric Peptides Derived from the Bothropstoxin-I Are Potent SARS-CoV-2 and Papain-like Protease Inhibitors
by: Marjorie C. L. C. Freire, et al.
Published: (2021-08-01) -
Structural elucidation of SARS-CoV-2 vital proteins: Computational methods reveal potential drug candidates against main protease, Nsp12 polymerase and Nsp13 helicase
by: Muhammad Usman Mirza, et al.
Published: (2020-08-01) -
In silico Exploration of Inhibitors for SARS-CoV-2's Papain-Like Protease
by: Tien Huynh, et al.
Published: (2021-02-01) -
SARS-CoV-2 Papain-Like Protease Potential Inhibitors—In Silico Quantitative Assessment
by: Adam Stasiulewicz, et al.
Published: (2021-04-01) -
Communicating about the Middle East respiratory syndrome outbreak to the international community and in-country foreigners, Republic of Korea, 2015
by: Minwon Lee, et al.
Published: (2016-02-01)