Transcription Factor KLF2 in Dendritic Cells Downregulates Th2 Programming via the HIF-1α/Jagged2/Notch Axis

Transcription Factor KLF2 in Dendritic Cells Downregulates Th2 Programming via the HIF-1α/Jagged2/Notch Axis

The adaptive immune response is tightly regulated by complex signals in dendritic cells (DCs). Although Th2 polarization is dictated by defined functional DC subsets, the molecular factors that govern the amplitude of these responses are not well understood. Kruppel-like factor 2 (KLF2) is a transcr...

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Bibliographic Details
Main Authors: Ye Xiong, Jerry B. Lingrel, Marcel Wuthrich, Bruce S. Klein, Neelakantan T. Vasudevan, Mukesh K. Jain, Mariam George, George S. Deepe
Format: Article
Language:English
Published: American Society for Microbiology 2016-06-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/7/3/e00436-16

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http://mbio.asm.org/cgi/content/full/7/3/e00436-16

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