Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries

Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries

Topologically associating domains (TADs) detected by Hi-C technologies are megabase-scale areas of highly interacting chromatin. Here Gong, Lazaris et al. develop a computational approach to improve the reproducibility of Hi-C contact matrices and stratify TAD boundaries based on their insulating st...

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Bibliographic Details
Main Authors: Yixiao Gong, Charalampos Lazaris, Theodore Sakellaropoulos, Aurelie Lozano, Prabhanjan Kambadur, Panagiotis Ntziachristos, Iannis Aifantis, Aristotelis Tsirigos
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03017-1

Internet

https://doi.org/10.1038/s41467-018-03017-1

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